Development and Characterization of Kojic Acid and Carnaúba Wax-Based Solid Lipid Microparticles

    Published on:December 2020
    Journal of Young Pharmacists, 2020; 12(4):309-313
    Original Article | doi:10.5530/jyp.2020.12.83

    Larissa Coelho Costa1, Bianca Oliveira Louchard1, Edilson Martins Rodrigues Neto1,*, Priscylla da Silva Giffony1, Fernanda Maria Teófilo Campos2, Tamara Gonçalves de Araujo1

    1Department of Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, CE, BRAZIL.


    Background: The treatment of dyschromia can be conducted using dermocosmetics containing depigmenting agents, such as kojic acid. Objectives: This study aimed the development and characterization of Carnaúba wax-based micro particles, in order to disseminate kojic acid in cosmetic and dermatological products. Methods: These elements were developed and characterized by electron microscopy and spectrophotometry, in addition to the evaluation of the encapsulation effectiveness and the release profile. Results: The different formulations showed that the variation of the concentrations of the active compound did not interfere with the Solid Lipid Micro particles (SLM) morphology, showing spherical shape and variation in their sizes. The formulation that showed the best yield was M1. All formulations showed low effective encapsulation effectiveness, varying approximately between 5 and 15%. Conclusion: The stirring speed and the stirring time are critical factors in the obtainment process and in the morphology of solid lipid micro particles.

    Key words: Kojic acid, Carnaúba, Lipid Microparticles.

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