N.V.L Suvarchala Reddy V*, Ganga Raju M, Sirisha S, Nikitha K
Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana, INDIA.
Abstract:
Objectives: Herbal treatment is a natural form of healing or alternative therapy to cure ailments or diseases of cognitive disorders. Methods: The methanolic whole plant extract of Acalypha indica was screened for its Antiepileptic and anxiolytic activity in rodent models. Molecular docking studies were employed to study interactions with GABA agonist’s active site. Results: MEAI showed a significant reduction in various phases of convulsions at 30 and 60 minutes and afforded significant protection against MES model. In PTZ, MEAI at a dose of 200 mg/kg protected 66.66% of the animals against seizures and did not affect the latency of seizures to any significant extent at a dose of 400 mg/kg protected 33.33% of the mice against seizures and significantly (* = p<0.0001, ** =p<0.002) increased the latency of the seizures. In INH induced convulsions MEAI at a dose of (200-400 mg/kg) significantly (* = p<0.0001, ** = p<0.05) delayed the duration of INH induced convulsions from 57.8±2.67s to 45.5±2.33, 32.8±1.62 respectively. In- vivo anti-anxiety activity MEAI at a dose of 200 and 400 mg/kg exhibited remarkable upsurge in time consumed as well as the number of entries into open arms of 200, and 400 mg/kg exhibited noteworthy upsurge in time consumed as well as the number of entries into open arms and time spent in neutral zone. Molecular docking studies confirmed the GABA agonist’s effects, and Glide scores order for all molecules reflected the experimental GABA agonists. Conclusion: From the exceeding consequences, it is vibrant that MEAI possesses antiepileptic and anti-anxiolytic activities.
