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Effect of Moringa oleifera Leaves Extract Against Hematology and Blood Biochemical Value of Patients with Iron Deficiency Anemia

1, 2, 3, 3, 3, 4★★ Corresponding author

  1. 1Graduate Program of Herbal Medicine, Faculty of Pharmacy, Universitas Indonesia, Kampus Baru UI Depok, INDONESIA.
  2. 2Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.
  3. 3Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Kampus Baru UI Depok, INDONESIA.
  4. 4Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Kampus Baru UI Depok, INDONESIA.

CORRESPONDENCE

Abdul Mun’im

Department of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Kampus Baru UI Depok, INDONESIA.

munim@farmasi.ui.ac.id

Received: 21-12-2016; Revised: 07-01-2017; Accepted: 21-01-2017.

Volume 9, Issue 1s · pp. s79-s84 · 2017 · DOI: 10.5530/jyp.2017.1s.20

ABSTRACT

Introduction: Approximately (24.8%) the world’s population suffers from anemia and 50% of an anemic case is due to iron deficiency. This study investigated the efficacy of Moringa oleifera L leaves to extract as an iron booster and supplement to help overcome anemia in the community.Methods: It was a randomized, double-blind, placebo-controlled study in anemic women (he moglobin 8-12g/dL), in which the water extract of moringa leaves was exam ined as an add-on therapy in the subject treated with ferrous sulfate (200mg/ tablet). Thirty-five women subject of 16-49 years old were divided into 17 of moringa leaves and 18 of control. The extract of moringa leaves of 1400 mg was formulated in capsules and was administrated daily for 3 weeks.Results: The result showed there were significantly increase of mean of hemoglobin (0.794±0.81 g/dL), ferritin (29.378±42.48 ng/mL), MCHC (Mean Corpuscular Haemoglobin Concentration) (2.459±2.86 g/dL), RDW (Red Distribution Wide) (1.4±2.07 %) and decreased of platelets (36529.41±59024.48 /uL). The con trol groups were significantly increased of mean of the hemoglobin (0.644± 0.83g/dL), erythrocytes (0.475±0.523 Tpt/L), hematocrit (2.189±l4.08 %), MCV (Mean Corpuscular Volume)(4.756±8.91 fL), MCH (2.183±2.47 pg) dan RDW (2.844±2.80%).The hematocrit (3.14±1.47%), MCH (Mean Corpuscular Hemo globin) (3.495±1.33 pg), MCHC (3.264±0.96 g/dL) values of moringa leaves were significantly higher whereas the platelets count (55251.63±23404/uL) of moringa leaves were significantly lower (p<0.05) than those of control group.Conclusion: It can be concluded that moringa leaves extract could improve iron deficiency anemia in women.

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    Suzana, D., Suyatna, F. D., a, A., Andrajati, R., Sari, S. P., & Mun’im, A. (2017). Effect of Moringa oleifera Leaves Extract Against Hematology and Blood Biochemical Value of Patients with Iron Deficiency Anemia. Journal of Young Pharmacists, 9(1s), s79-s84. https://doi.org/10.5530/jyp.2017.1s.20

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    © 2017 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0