Nephroprotective Effect of Pterocarpus indicus Willd. Leaves : Observation of Urine Volume, Sodium and Potassium Levels in Gentamicin-induced Rat Model
1, 1, 2
- 1Laboratory of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, INDONESIA.
- 2Laboratory of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, INDONESIA.
CORRESPONDENCE
Fadlina Chany Saputri
Laboratory of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, INDONESIA.
Received: 19-12-2016; Revised: 07-01-2017; Accepted: 13-01-2017.
Volume 9, Issue 1s · pp. s85-s88 · 2017 · DOI: 10.5530/jyp.2017.1s.21
ABSTRACT
Introduction: Kidney disease is a common disease worldwide. The leaves from Pterocarpus indicus Willd. is alternatively applied for prevention therapy of patients with kidney diseases.Objective:The aim of this study to demonstrate the scientific nephroprotective effect of water-boiled P. in dicus leaves evaluated from urine volume, sodium and potassium levels.Materials and Methods: Thirty male Sprague-Dawley rats were divided into five treatment groups; group I (control), group II (gentamicin-induced 80 mg/kg i.p from day 15 to 21), and group III to V (induced; variated dos es respectively 28.8 mg/kg; 57,6 mg/kg; and 115,2 mg/kg bw which was given for 21 days orally as single doses). Nephroprotective effects were observed as abnormal from levels of urinary volume.Results: Obtained results on sodium and potassium levels show the group given the highest dose (115,2 mg/kg) resulted in decreased sodium levels and increased lev els of urinary potassium as well as having a significant difference (p<0,05) to the induction group. Observed 24-hour urine volume, however, did not show any significant signs of nephroprotective effects.Conclusion: It can be concluded that the leaves of P.indicus have potential nephroprotective properties.
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Saputri, F. C., Adiyati, Z., & Waty, D. R. (2017). Nephroprotective Effect of Pterocarpus indicus Willd. Leaves : Observation of Urine Volume, Sodium and Potassium Levels in Gentamicin-induced Rat Model. Journal of Young Pharmacists, 9(1s), s85-s88. https://doi.org/10.5530/jyp.2017.1s.21
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