Objective: To evaluate the combined effects of lipoic acid and nuclear CMP on arousal and sensory cortical activity in normal healthy volunteers. Method: Eighty healthy volunteers enrolled in this study, the volunteers were divided into four groups’. Group A: take a placebo and regarded as controlling. Group B: take nucleo CMP capsule 5mg/day. Group C: take lipoic acid 400 mg/day. Group D: take nucleo CMP and lipoic acid/ day. The duration of treatment was two weeks. CFFF tests measured via Leeds psychomotor battery tester. Student t-test, simple correlation and ANOVA test via SPSS version 18, taking p<0.05 as the lowest limit of significance. Results: lipoic acid improves fusion frequency (ascending) insignificantly and flicker (descending) frequency significantly in normal healthy volunteers. Nucleo CMP leads to a significant amelioration of critical flicker frequency, flicker percent and fusion percent p<0.05, but, it produced insignificant effects on a flicker index, critical fusion frequency and fusion index p>0.05. Combined lipoic acid and Nucleo CMP produced significant effects on critical flicker frequency, critical fusion frequency, flicker percent and fusion percent p<0.05, but they produced insignificant effects on a flicker index, fusion index, and CFFF p>0.05. Conclusion: lipoic acid and nucleo CMP produced significant arousal effects on normal healthy volunteers and improve cognitive functions.
Key words: CFFF, Lipoic acid, Nucleo CMP, Sensory cortical activity.