Antihistaminic Effect of Various Extracts of Punica granatum Linn. Flower Buds

    Published on:
    Journal of Young Pharmacists, 2009; 1(4):332-335
    Pharmacognosy | doi:10.4103/0975-1483.59321

    Barwal SB, Nirmal Sunil A, Dhasade VV, Patil MJ, Pal SC1, Mandal Subhash C2

    Department of Pharmacognosy, Pravara Rural College of Pharmacy, Loni, M.S.;

    1Department of Pharmacognosy, NDMVP College of Pharmacy, Nashik, M.S;

    2Pharmacognosy and Phytochemistry Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.


    Punica granatum Linn. (Punicaceae) ß ower buds are used in the treatment of asthma traditionally, so the present work was undertaken to prove it scientiÞ cally using suitable animal models. Antihistaminic principles are useful in the treatment of asthma,;hence, in present work antihistaminic activity of various extracts of P. granatum ß ower buds was checked using clonidine-induced catalepsy and haloperidol-induced catalepsy in Swiss albino mice at the dose of 50 and 100 mg/kg, p.o. The results showed that ethanol extracts (100 mg/kg, p.o.) are having signiÞ cant antihistaminic activity amongst other extracts. Thus, it can be concluded that tannins from the ß ower buds of P. granatum may be responsible for antihistaminic activity and may have potential role in the treatment of asthma.

    Key words: Antihistaminic, catalepsy, clonidine, haloperidol, Punica granatum.