Punica granatum Linn. (Punicaceae) ß ower buds are used in the treatment of asthma traditionally, so the present work was undertaken to prove it scientiÞ cally using suitable animal models. Antihistaminic principles are useful in the treatment of asthma,;hence, in present work antihistaminic activity of various extracts of P. granatum ß ower buds was checked using clonidine-induced catalepsy and haloperidol-induced catalepsy in Swiss albino mice at the dose of 50 and 100 mg/kg, p.o. The results showed that ethanol extracts (100 mg/kg, p.o.) are having signiÞ cant antihistaminic activity amongst other extracts. Thus, it can be concluded that tannins from the ß ower buds of P. granatum may be responsible for antihistaminic activity and may have potential role in the treatment of asthma.
Key words: Antihistaminic, catalepsy, clonidine, haloperidol, Punica granatum.
