Synthesis of Some New Isoxazoline Derivatives of Chalconised Indoline 2-one as a Potential Analgesic, Antibacterial and Anthelmimtic Agents
1★, 2, 1, 2, 3★ Corresponding author
- 1Department of Pharmaceutical Chemistry, Vaageswari College of Pharmacy, INDIA.
- 2Vaageswari Institute of Pharmaceutical Sciences, Karimnagar,, INDIA.
- 3Koringa College of Pharmacy, Korangi, Andhra Pradesh, INDIA.
CORRESPONDENCE
Mondal P
Department of Pharmaceutical Chemistry, Vaageswari College of Pharmacy, INDIA.
Volume 4, Issue 1 · pp. 38-41 · 2012 · DOI: 10.4103/0975-1483.93574
ABSTRACT
Two simple, rapid, and extractive spectrophotometric methods were developed for the determination of tropicamide (TPC). These methods are based on the formation of ionpair complexes between the basic nitrogen of the drug with bromocresol purple (BCP) and methyl orange (MO) in acidic buffer solution. The formed complexes were extracted with chloroform and measured at 408 and 427 nm using BCP and MO, respectively. Beer's law was obeyed in the range 1.0-16 µg ml-1 with correlation coefficient (n=6) ≥0.9991. The molar absorpitivity, Sandell sensitivity, detection, and quantification limits were also calculated. The composition of the ion pairs was found 1:1 by Job's method. The proposed methods have been applied successfully for the analysis of TPC in pure and in its eye drops.
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P, M., S, J., A, B., R, R., & LK, K. (2012). Synthesis of Some New Isoxazoline Derivatives of Chalconised Indoline 2-one as a Potential Analgesic, Antibacterial and Anthelmimtic Agents. Journal of Young Pharmacists, 4(1), 38-41. https://doi.org/10.4103/0975-1483.93574
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© 2012 Author(s)
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