Article · Volume 4, Issue 1 · pp. 38-41
Synthesis of Some New Isoxazoline Derivatives of Chalconised Indoline 2-one as a Potential Analgesic, Antibacterial and Anthelmimtic Agents
Mondal P1, Jana S2, Balaji A1, Ramakrishna R2, Kanthal LK3
- 1Department of Pharmaceutical Chemistry, Vaageswari College of Pharmacy, INDIA.
- 2Vaageswari Institute of Pharmaceutical Sciences, Karimnagar,, INDIA.
- 3Koringa College of Pharmacy, Korangi, Andhra Pradesh, INDIA.
Abstract
Two simple, rapid, and extractive spectrophotometric methods were developed for the determination of tropicamide (TPC). These methods are based on the formation of ionpair complexes between the basic nitrogen of the drug with bromocresol purple (BCP) and methyl orange (MO) in acidic buffer solution. The formed complexes were extracted with chloroform and measured at 408 and 427 nm using BCP and MO, respectively. Beer's law was obeyed in the range 1.0-16 µg ml-1 with correlation coefficient (n=6) ≥0.9991. The molar absorpitivity, Sandell sensitivity, detection, and quantification limits were also calculated. The composition of the ion pairs was found 1:1 by Job's method. The proposed methods have been applied successfully for the analysis of TPC in pure and in its eye drops.
Keywords: Analgesic; anthelmintic; antibacterial; in vitro; isatin; isoxazoline
The full text of this article, with its figures and tables, is its PDF, shown below. Open the PDF in a new tab.