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Formulation Development and Evaluation of Alginate Microspheres of Ibuprofen

1★, 2, 3, 4, 5, 6★ Corresponding author

  1. 1Department of Pharmaceutics, College of Pharmacy, Chitkara University, Patiala, Punjab, INDIA.
  2. 2Pharmaceutics, INDIA.
  3. 3Pharmacology, Rajendra Institute of Technology and Sciences, Sirsa, Haryana, INDIA.
  4. 4Pharmaceutics, M. D. University, Rohtak, INDIA.
  5. 5Pharmaceutical Chemistry, Malwa College of Pharmacy, Bhatinda, Punjab, INDIA.
  6. 6Pharmaceutics, NCRD Sterling Institute of Pharmacy, Nerul, Navi Mumbai, Maharashtra, INDIA.

CORRESPONDENCE

Nagpal M

Department of Pharmaceutics, College of Pharmacy, Chitkara University, Patiala, Punjab, INDIA.

nagpalmanju@ymail.com

Volume 4, Issue 1 · pp. 13-16 · 2012 · DOI: 10.4103/0975-1483.93573

ABSTRACT

The present study was designed to investigate the effects of different variables on the release profile of ibuprofen microspheres formulated using modified emulsification method. Eight batches of microspheres (F1–F8) were prepared by applying 2³ factorial design. The amount of sodium alginate, amount of calcium chloride, and amount of magnesium stearate were selected as formulation variables. All the batches were evaluated in terms of percentage yield, percentage encapsulation efficiency and in vitro release characteristics. The batch F7 was found to be optimum batch and was further characterized via scanning electron microscopy (SEM) and particle size analysis. Multiple linear regression was applied to confirm significant effect of each variable on release characteristics. The model developed in the present study can be effectively utilized to achieve the formulation with desired release characteristics.

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    M, N., DK, M., P, R., H, D., S, G., & G, D. (2012). Formulation Development and Evaluation of Alginate Microspheres of Ibuprofen. Journal of Young Pharmacists, 4(1), 13-16. https://doi.org/10.4103/0975-1483.93573

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    © 2012 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0