Objectives: To Study the hepatoprotective and antioxidant activity of the whole plant, ethanolic extract of Tephrosia villosa (EETV). Methods: Hepatoprotective effect of EETV is studied against carbon tetrachloride (CCl4) and paracetamol-induced hepatotoxicity in rats. Individual rats received EETV doses of 200 and 400 mg/kg (w/w) for seven days, respectively. On the 7th day, induced hepatotoxicity in all rats of all groups by 1.25 ml/kg (i.p) CCl4 and paracetamol 1gm/kg/p.o. Determining effects of ETEV on antioxidant activity, SGOT, SGPT, ALP, and direct bilirubin were, and also performed a histopathological exam of the liver sections. Results: The extract prevented the exhaustion of glutathione and catalase levels and increased lipid peroxidation levels against CCl4 induced and Paracetamol liver injury in rats. By histopathological evidence, EETV also significantly decreased biochemical levels of liver enzymes with high hepatoprotection at 200 mg/kg. Conclusion: Present study results strongly reveal that EETV has hepatoprotective and antioxidant activity against CCl4 and paracetamolinduced hepatic impairment in experimental animals.
Key words: Tephrosia villosa, Hepatoprotective, Antioxidant, Carbon tetrachloride, Paracetamol, Silymarin.