Aim: The aim of the present study was to evaluate the antidiabetic potential of “kathakakhadiradi kashyam” (KKS) an indigenious polyherbal ayurvedic formulation in streptozotocin induced diabetes rat model. Methodology: Initially a single day oral glucose tolerance test was conducted and the effective dose (1.08 ml/kg) found in this study was taken for further evaluation in the 28 day continues administration study. The effects were compared with diabetic control and standard control groups. Result and Conclusion: The ratio of percentage reduction observed between standard drug treated group (Glibenclamide) and KKS treated group from the 7th day to 14th, 21st and 28th day are 43.99:35.54, 46.53:44.4, 53.88:43.5 respectively. When compared with all other groups KKS treated group shows more similar glucose lowering activities. The study also correlates food, water intake and body weight changes in different groups throughout the study. The results shows that KSS posses promising antidiabetic activity. More detailed molecular level studies and toxicological evaluations are necessary to conform the safety and efficacy of KKS for clinical practice.
Key words: Kathakakhadiradi kashyam, Polyherbal, Antidiabetic activity, Oral glucose tolerance test.
