Synthesis and Biological Evaluation of some 3b-hydroxy-lup-20(29)-en-28-oic Acid Derivatives

    Published on:August 2016
    Journal of Young Pharmacists, 2016; 8(4):319-323
    Original Article | doi:10.5530/jyp.2016.4.5
    Authors:

    Prince Prashant Sharma1, Anurag2, Ram Kumar Roy3, Rajneesh Dutt Kaushik4, Vipin Kumar Sharma5

    1Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.

    2Meerut Institute of Engineering and Technology (MIET), NH-58 Meerut-Delhi Bypass, Meerut, Uttar Pradesh, INDIA.

    3Innovative College of Pharmacy, Knowledge Park-ii, Greater Noida, Uttar Pradesh, INDIA.

    4Department of Chemistry, Faculty of Sciences, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.

    5Department of Pharmaceutical Sciences, Faculty of Medical Sciences and Health, Gurukula Kangri University, Haridwar-249404, Uttarakhand, INDIA.

    Abstract:

    Objective: The present study projected to the synthesis of 3b-Hydroxy-lup- 20(29)-en-28-oic acid analogues in order to evaluate their possible biological activity. In addition, the structure–activity relationship is also investigated. Method: BA derivatives were prepared by conjugating 3b-Hydroxy-lup- 20(29)-en-28-oic acid with different amines through carbomyl linkage. Structures of synthesized compounds were elucidated by spectral data. Cytotoxic evaluation was done by CAM assay and MTT assay. Results: Among the synthesized compounds, Compound 7showed a pronounced cytotoxicity in antiangiogenic assay as well as compound ECV-304 cell line. Compound 10 also showed good cytotoxic activity. While compounds 6 and 8 showed moderate activity against A-549 and MCF-7 respectively. Conclusion: It is concluded that synthesized BA analogues are biologically active and developed into useful anticancer agents.

    Key words: Triterpenoids, Lupenoic acid, Carbomyl Linkage, Anticancer activity, MTT Assay.

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