Temperature Standardization and Quality Standard of Kushta e Gaodanti by Adopting Classical and Modern Methods

    Published on:February 2022
    Journal of Young Pharmacists, 2022; 14(1):67-72
    Original Article | doi:10.5530/jyp.2022.14.13
    Authors:

    Nazeem Fahamiya1,*, Shafeek G Ansari2, Ansari ZA1, Mohammad Aslam3, Zakir Mohammad4, Mohamed Shiffa5, Mohammad Zahid Ashraf1,*

    1Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, INDIA.

    2Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, INDIA.

    3Department of Ilmul Advia, School of Unani Medical Education and Research, Jamia Hamdard, New Delhi, INDIA.

    4Department of Ilmul Advia, National Research Institute of Unani Medicine for Skin Disorders, Hyderabad, INDIA.

    5Department of Study in Unani, Institute of Indigenous Medicine, University of Colombo, SRI LANKA.

     

    Abstract:

    Background: Kushta Gaodanti (KG) is an essential Unani dosage form prepared by calcination according to classical texts. Standardization is paramount important to check purity and genuineness of the product. However, there are some drawbacks in the calcination process and assessing quality of the drug as per classical method. Hence, this study was aimed to evaluate the quality of KG by classical and modern methods and to develop a quality standard for KG. Methods: A multidisciplinary approach utilizing modern analytical techniques with classical tests was used. Thermogram developed when preparing KG by classical method was used to prepare the drug by Furnace method. The quality of both samples was evaluated on classical parameters like finger test, fineness test, floating test, grain test and wall test and modern physicochemical parameters like bulk density, tapped density, Hausner’s ratio, Carr’s index, pH, Loss on drying, ash values, and extractive values. Characterization using X-ray diffraction, Scanning Electron Microscopy, Energy Dispersive X-ray Analysis, Fourier-Transform Infrared spectroscopy, absorption spectroscopy, Zeta size and potential analysis, and heavy metal analysis have also been carried out to establish the quality standard of KG with modern analytical techniques. Results: The results of the tests done for both the preparations are comparable within experimental error when comparing with each other but non-significant differences were observed in certain parameters. Conclusion: The physicochemical and analytical parameters evaluated in this study may be considered as standard reference for KG. Furthermore, the thermogram developed in this study can be utilized to prepare the Kushta Gaodanti by the furnace method.

    Key words: Kushta Gaodanti, Arthralgia, Unani Medicine, Gypsum, Physicochemical.

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