Evaluation of the Effects of Propolis and Xylitol Chewable Tablets on the Salivary Concentrations of Oral Micro-organisms in Orthodontic Patients: A Pilot Study

    Published on:March 2021
    Journal of Young Pharmacists, 2021; 13(1):68-71
    Original Article | doi:10.5530/jyp.2021.13.15

    Érica Cardoso Siqueira1, Fernanda Maria Teófilo Campos2, Jerlyson Coelho Mendes3, Larisse Nogueira De Lima3, Ruth Sousa Araújo3, Nara Karoliny Sousa Gomes3, Luiza Rayanne da Silva Lima3, Rodrigo Freires Nogueira3, Maria Célia da Silva Rocha3, Raimundo Juarez Viana Barros3, Carlos Eduardo Marques Bandeira3, Jair Paulino de Sales3, Edmir Geraldo de Siqueira Fraga4, Lara da Silva Nogueira3, Carlos Augusto Oliveira Meneses5, Roberto Lima de Albuquerque6, Thayanne Brasil Barbosa Calcia7, Patricia Leal Dantas Lobo8, Edilson Martins Rodrigues Neto8,*

    1Veterinary Medicine School, State University of Ceara, Fortaleza, CE, BRAZIL.

    2Health Multidisciplinary Residence Program, Public Health School from Ceara State, Fortaleza, CE, BRAZIL.

    3Pharmacy College, Catholic University Center of Quixadá, Quixadá, CE, BRAZIL.

    4Department of Health Sciences, Division of Microbiology, Santa Casa de São Paulo School of Medical Sciences, São Paulo, SP, BRAZIL.

    5Dentistry College, Unichristus University Center, Fortaleza, CE, Brazil.

    6Pharmacy College, Unifanor University Center, Fortaleza, CE, Brazil.

    7Dentistry Faculty, Arthur Sá Earp Neto University Center, Petropolis, RJ, BRAZI.

    8Department of Pharmacy, Dentistry and Nursing College, Federal University of Ceara, Fortaleza, CE, BRAZIL.


    Objectives: This study sought to evaluate the effectiveness of red propolis and xylitol chewable tablets in reducing concentrations of micro-organisms such as Streptococcus mutans (SM) and gram-negative bacteria (GNB). Methods: A total of 12 volunteers of both sexes presenting no caries (ICDAS II 0), users of fixed orthodontic appliances and with visible plaque index were randomly assigned to one of two groups. Was to determine the variations in the concentrations of SM and GNB in the saliva before and after the administration of the chewable tablets. The appearance of adverse reactions and side effects was analyzed. The Mann-Whitney (parametric) test was used for pairwise comparisons of means. The Wilxocon test was also used. Results: The study revealed that the propolis and xylitol chewable tablets had antimicrobial activity, reducing the concentration of GNB by -1.39 log10 CFU/mL (p = 0.036) and compared to placebo (p = 0.004698). There was a significant reduction of SM of -0.22 log10 CFU/mL (p = 0.031) and compared to placebo (p = 0.002165). Conclusion: Thus, in addition to the good safety profile, with a low rate of adverse effects, red propolis and xylitol tablets proved to be an effective potential low-cost alternative to combat dental caries and other periodontal diseases.

    Key words: Propolis, Xylitol, Chewable tablets, Streptococcus mutans, Dental decay.

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