Biomedical Applications of Calcium Phosphate Ceramics as Biomaterials

    Published on:September 2020
    Journal of Young Pharmacists, 2020; 12(3):190-192
    Review Article | doi:10.5530/jyp.2020.12.58

    Karine Jorge Alves Bezerra1, Ismael Nobre de Sena Silva1, Leonardo Jorge Alves Bezerra1, Luíza Maria Oliveira Cavalcante1, Dyêggo Carvalho Amorim1, Diego Pessoa Jucá Machado1, Fernando Antônio Mendes Bezerra Ximenes1, Ana Carolina Sales Almeida1, Lara Vasconcelos Costa1, Nicolle Vichnevski Alencar Araripe Nunes1, Lidia Audrey Rocha Valadas2,*

    1School of Medicine, Unichristus, Fortaleza - Ceará, BRAZIL.

    2School of Pharmacy, Dentistry and Nursing School, Federal University of Ceará, Fortaleza - Ceará, BRAZIL.


    The application of ceramics as bone substitutes is mainly due to their bioactivity property, presenting an ability to adhere to adjacent bone tissues. In the last decades the number of researches with bioactive ceramics in bone grafts has grown. The objective of the present study was to perform a literature review of the application of calcium phosphate ceramics in the biomedical fields. For this present study, 21 articles indexed indatabases, mainly through in PubMed and LILACS were selected and published between the years 2004 to 2019. Calcium phosphates are examples of bioceramics and are part of a group of combinations that constitute the natural structure of bones humans and teeth. The main reasons for calcium phosphate biomaterials standing out for bone replacement are their facility of use and biocompatibility. Current research indicates that the association of hydroxyapatite (HA) with tricalcium phosphate β (TCP-β) promotes better results regarding bone neoformation, showing promising results in the biomedical and biomaterials area, in the replacement of bone tissues. Synthetic bioactive ceramics have several applications and efficacy in the biomedical fields. HA and TCP-β have several properties scientifically demonstrated, the association of both being the result of the search for new materials and their improvement.

    Key words: Biomaterials, Grafts, Calcium phosphate, Hydroxyapatite, Ceramics.

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