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Effect of Permeation Enhancers on the Release and Permeation Kinetics of Oxytetracycline Hydrochloride Organogel Formulations

1★, 2, 3, 3★ Corresponding author

  1. 2Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar, INDIA.
  2. 1Sagar Institute of Pharmaceutical Sciences, INDIA.
  3. 3Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, INDIA.

CORRESPONDENCE

Nandini D

Sagar Institute of Pharmaceutical Sciences, INDIA.

pharmanandini@gmail.com

Volume 1, Issue 4 · pp. 285-289 · 2009 · DOI: 10.4103/0975-1483.59314

ABSTRACT

Oxytetracycline HCl is an antibacterial drug used in the treatment of acne vulgaris and dermatitis. Its oral bioavailability is intermediate i.e., 60% and it is rapidly excreted through renal route. This drug has many side effects such as epigastric pain, nausea, vomiting, diarrhea, hypersensitivity, and tooth discoloration when taken orally. To overcome the side effects and to increase the bioavailability of Oxytetracycline HCl, topical formulations were prepared. Organogels were prepared using sorbitan monostearate as gelling agent and isopropyl myristate as vehicle with different permeation enhancers. The prepared formulations were evaluated for drug content, viscosity, extrudability, homogeneity, skin irritation test, in vitro drug release, and antimicrobial activity. A formulation containing eucalyptus oil with isopropyl myristate, showed better in vitro permeation and higher antimicrobial activity as compared to other formulations with different penetration enhancers.

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    D, N., NS, C., A, C., & K, P. (2009). Effect of Permeation Enhancers on the Release and Permeation Kinetics of Oxytetracycline Hydrochloride Organogel Formulations. Journal of Young Pharmacists, 1(4), 285-289. https://doi.org/10.4103/0975-1483.59314

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    © 2009 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0