Objectives: Herbal therapy is a natural practice of curative or substitute remedy to treat disorders or illnesses aimed at the management of cognitive ailments. Memory loss is a shortfall in recollection triggered by brain impairment or illness, but it can also be initiated briefly by the usage of numerous tranquilizing and hypnotic medications. Methods: In present study the methanolic leaf extract of Tecoma stans (METS) was screened for its Anti-amnesic activity in rodent models. The various phytochemical constituents like alkaloids, flavonoids, phenolics, terpenoids, tannins, sterols, saponins, glycosides, amino acids and carbohydrates present in the extract were identified by using GC-MS analysis. Results: Toxicity studies revealed that the extract was safe upto 2000 mg/kg, bd.wt. as per OECD guidelines 425. In-vivo anti-amnesic activity was accomplished in diazepam and aluminium induced amnesic models by actophotometer, rotarod and cook’s pole climbing apparatus. Various biochemical estimates like AChE, TBARS, GSH and SOD and histopathological studies of mice brain were performed in aluminium induced amnesic model. The in- vitro cholinesterase activity is evaluated using Ellman’s assay. METS exhibited noteworthy enhancement in intellectual diminishing in diazepam and aluminum chloride induced amnesic models and also suggestively decreased brain AChE and oxidant enzyme factors like TBARS, GSH and SOD levels and moderate inhibitory activities in ChE’s assay. Conclusion: From the results it is clear that the methanolic leaf extract of Tecoma stans possess anti-amnesic activity. Key words: Tecoma stans, Anti-amnesia, Memory, Acetylcholinesterase, Aluminium chloride, Ellman’s assay.