Journal of Young Pharmacists logo
Submit
Journal of Young PharmacistsACADEMIC PUBLISHING
Article

The Antifungal Effect of some 4-Chloro-6-Methoxy-N, N-Dimethylpyrimidin-2-Amine Derivatives Containing a Heterocyclic Compound on the Important types of Fungi

1, 2, 1★, 1★ Corresponding author

  1. 1Department of Chemistry, College of Science, University of Babylon, IRAQ.
  2. 2Department of Biology, College of Science, University of Babylon, IRAQ.

CORRESPONDENCE

Mahmoud Hussein Hadwan

Department of Chemistry, College of Science, University of Babylon, IRAQ.

mahmoudhadwan@gmail.com

Received: 03-04-2017; Revised: 23-05-2017; Accepted: 15-07-2017.

Volume 9, Issue 4 · pp. 463-467 · 2017 · DOI: 10.5530/jyp.2017.9.91

ABSTRACT

Objective: 4-methoxy-N, N-dimethyl-6-(phenylthio) pyrimidin-2-amine, 4-(benzo[d]thiazol-2-ylthio)-6-methoxy-N,N-dimethylpyrimidin-2-amine, 4-(4-(1,2,3-selenadiazol-4-yl)phenoxy)-6-methoxy-N,N 2-amine and 4-(4-(1,2,3-thiadiazol-4-yl)phenoxy)-6-methoxy-N,N 2-amine have been synthesized.Method: The prepared compounds were synthesized by nucleophilic displacement of chloride substituted in pyrimidine heterocyclic ring.Results: The synthesized compounds were being identified by different methods included TLC technique, IR, 1H-NMR and 13C-NMR spectrophotometers. All compounds confirmed by elemental analysis. The biological activity of these new compounds investigated against some fungi like Aspergillus terreus and Aspergillus niger, the results was Aspergillus terreus more effected by antifungal compare with Aspergillus niger, the effect ration 0.98, 1.32 with 200μM respectively and the compound number (2) has more effect than other compounds.Conclusion: It is concluded that synthesized dimethylpyrimidin-derivatives are biologically active and developed into useful Antifungal agents.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Jafar, N. N., Mahdi, I. M. A., Hadwan, M. H., & Alameri, A. A. (2017). The Antifungal Effect of some 4-Chloro-6-Methoxy-N, N-Dimethylpyrimidin-2-Amine Derivatives Containing a Heterocyclic Compound on the Important types of Fungi. Journal of Young Pharmacists, 9(4), 463-467. https://doi.org/10.5530/jyp.2017.9.91

    Copyright and licence

    © 2017 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0