Screening of new compounds for the management of erectile dysfunction

ABSTRACT

Objective/Background:Erectile dysfunction, a male sexual dysfunction generally develops due to impairment of relaxation of penile smooth muscles and arteries. Inhibitors of phosphodiesterase type 5 (PDE5) enzyme like in sildenafi l, vardenafi l, tadalafi l etc. are in clinical use for the management of erectile dysfunction. Ongoing research focuses on development of potent medicine with fewer side effects. Objective of this article is to discuss and demonstrate procedures available to screen new compounds for the management of erectile dysfunction.Methodology: Many animal models (mice, rat, cat, rabbit, dog etc.) are available to screen new chemical compounds for increasing erectile function. In vitro (using isolated corpus cavernosum smooth muscle of penile tissue) and in vivo (measuring intracavernosal pressure) studies may be performed for screening new compounds. In this article, we discuss about two such screening procedures using rat as an animal model. Results and discussion: Compounds those relax isolated rat corpus cavernosum smooth muscles signifi cantly in vitro may increase penile erection in humans. Similarly, the compounds those increase intracavernosal pressure by relaxing erectile smooth muscle and penile arteries in rat may increase erectile function in humans.Conclusion: Rat is a suitable model for screening new compounds to manage erectile dysfunction.

KEYWORDS

• Corpus cavernosum smooth muscle
• intracavernosal pressure
• mean arterial pressure

Showing references and in-text citations exactly as published.

• DOI10.5530/jyp.2014.4.9Copy

Copyright and licence

© 2014 Author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0

RELATED ARTICLES

Matched on section and article type within this issue of JYP.

• Communication · VOLUME 6, ISSUE 4Quantitative determination of donepezil hydrochloride by a simple and accurate synchronous spectrofl uorimetric method in human plasmaChintan Patel, Nrupesh Patel, Charmy Kothari · pp. 47-50Short CommunicationSame type: Communication
• Communication · VOLUME 6, ISSUE 4Evaluation of oral antidepressant drugs for adaptation to the simple suspension methodHiroyuki Hichiya, Yusuke Mimura, Nobumitsu Hanioka · pp. 56-60Short CommunicationSame type: Communication