Cardioprotective Effects of Lagenaria siceraria Fruit Juice on Isoproterenol-induced Myocardial Infarction in Wistar Rats: A Biochemical and Histoarchitecture Study

    Published on:
    Journal of Young Pharmacists, 2011; 3(4):297-303
    Pharmacology | doi:10.4103/0975-1483.90241
    Authors:

    Upaganlawar A, Balaraman R

    Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara, Gujarat, India.

    Abstract:

    The present study was designed to evaluate the cardioprotective effects of Lagenaria siceraria fruit juice in isoproterenol-induced myocardial infarction. Rats injected with isoproterenol (200 mg/kg, s.c.) showed a significant increase in the levels of serum uric acid, tissue Na ++ and Ca ++ ions and membrane-bound Ca +2 -ATPase activity. A significant decrease in the levels of serum protein, tissue K + ion, vitamin E level, and the activities of Na + /K + -ATPase and mg +2 -ATPase was observed. Isoproterenol injected rats also showed a significant increase in the intensity of lactate dehydrogenase isoenzyme and histopathologic alterations in the heart. Treatment with L. siceraria fruit juice (400 mg/kg/day, p.o.) for 30 days and administration of isoproterenol on 29 th and 30 th days showed a protective effect on altered biochemical and histopathologic changes. These findings indicate the cardioprotective effect of L. siceraria fruit juice in isoproterenol-induced myocardial infarction in rats.

    Key words:Antioxidant activity,isoproterenol,Lagenaria siceraria,myocardial infarction.

     

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