Effects of Cynodon dactylon on Stress-Induced Infertility in Male Rats

    Published on:
    Journal of Young Pharmacists, 2011; 3(1):26-35
    Pharmacognosy | doi:10.4103/0975-1483.76416
    Authors:

    Chidrawar VR, Chitme HR1, Patel KN2, Patel NJ3, Racharla VR4, Dhoraji NC5, Vadalia KR6

    Department of Pharmacology, Shree H. N. Shukla Institute of Pharmaceutical Education and Research, Gujarat, India,

    1Department of Pharmacology, Oman Medical College, Azaiba-Muscat, Sultanate of Oman,

    2Department of Pharmacognosy, Arihant School of Pharmacy and Bio-Research Institute, Gandhinagar, Gujarat,

    3Department of Pharmacology, Saraswati Institute of Pharmaceutical Sciences At: Dhanap, Dist. Gandhinagar, Gujarat,

    4Drug Regulatory Affairs, Emcure Pharmaceutical Pvt. Ltd., Pune, Maharashtra,

    5Department of Pharmacology, H.S.K. College of Pharmacy, Bagalkot, Karnataka,

    6Department of Pharmaceutical Chemistry, Shree H. N. Shukla Institute of Pharmaceutical Education and Research, Rajkot, Gujarat, India.

    Abstract:

    Cynodon dactylon (Family: Poaceae) is known to be a tackler in Indian mythology and is offered to Lord Ganesha. It is found everywhere, even on waste land, road side, dry places, and spreads vigorously on cultivated ground. This study was carried out with an objective to test if the constituents of this plant are useful in coping stressinduced sexual In this study, we considered immobilization stress to induce male infertility and the effect of C. dactylon in restoration of the dysfunction was evaluated by considering sexual behavioral observations, sexual performance, fructose content of the seminal vesicles, epididymal sperm concentration and histopathological examinations as parameters. Treatment of rats under stress with methanolic extract of C. dactylon has shown a promising effect in overcoming stress-induced sexual dysfunction, sexual performance, fructose content, sperm concentration and its effect on accessory sexual organs and body weight. We conclude that active constituents of C. dactylon present in methanolic extract have a potent aphrodisiac and male fertility activity.

    Key words: Cynodon dactylon, infertility, sperm count, stress, testosterone.

     

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