Formulation and Optimization of Mucoadhesive Nanodrug Delivery System of Acyclovir
1★, 1, 1★ Corresponding author
- 1Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bangalore, INDIA.
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Bhosale UV
Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bangalore, INDIA.
Volume 3, Issue 4 · pp. 275-283 · 2011 · DOI: 10.4103/0975-1483.90236
ABSTRACT
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infections, with an oral bioavailability of only 10-20% [limiting absorption in gastrointestinal tract to duodenum and jejunum] and half-life of about 3 h, and is soluble only at acidic pH (pKa 2.27). Mucoadhesive polymeric nanodrug delivery systems of acyclovir have been designed and optimized using 2 3 full factorial design. Poly (lactic-co-glycolic acid) (PLGA) (50:50) was used as the polymer along with polycarbophil (Noveon AA-1) as the mucoadhesive polymer and pluronic F68 as the stabilizer. From the preliminary trials, the constraints for independent variables X 1 (amount of PLGA), X 2 (amount of pluronic F68) and X 3 (amount of polycarbophil) have been fixed. The dependent variables that were selected for study were particle size (Y 1), % drug entrapment (Y 2) and % drug release in 12 h (Y3). The derived polynomial equations were verified by check point formulation. The application of factorial design gave a statistically systematic approach for the formulation and optimization of nanoparticles with the desired particle size, % drug release and high entrapment efficiency. Drug: Polymer ratio and concentration of stabilizer were found to influence the particle size and entrapment efficiency of acyclovir-loaded PLGA nanoparticles. The release was found to follow Fickian as well as non-Fickian diffusion mechanism with zero-order drug release for all batches. In vitro intestinal mucoadhesion of nanoparticles increased with increasing concentration of polycarbophil. These preliminary results indicate that acyclovir-loaded mucoadhesive PLGA nanoparticles could be effective in sustaining drug release for a prolonged period.
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UV, B., V, K. D., & N, J. (2011). Formulation and Optimization of Mucoadhesive Nanodrug Delivery System of Acyclovir. Journal of Young Pharmacists, 3(4), 275-283. https://doi.org/10.4103/0975-1483.90236
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