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Synthesis, Characterization, and Biological Evaluation of certain 6-methyl-2(3H)-benzo-1, 3-thiazolyl-1'-ethylidene-2-(o, p- Substituted Acetophenones) Hydrazine Analogs

1★, 1, 1, 1, 2★ Corresponding author

  1. 1G.H.G Khalsa College of Pharmacy, Gurusar Sadhar-141104, Punjab, INDIA.
  2. 2Department of Biotechnology, Punjab University, Chandigarh, INDIA.

CORRESPONDENCE

Alang G

G.H.G Khalsa College of Pharmacy, Gurusar Sadhar-141104, Punjab, INDIA.

gavrup2000@gmail.com

Volume 2, Issue 4 · pp. 394-398 · 2010 · DOI: 10.4103/0975-1483.71636

ABSTRACT

In the present study, five new derivatives (GG4 to GG8) of benzothiazoles were synthesized and evaluated against Staphylococcus aureus (MTCC 737), Pseudomonas aeruginosa (MTCC 424), Escherichia coli (MTCC 1687), and yeast-like fungi Candida tropicalis. p-Toluidine on treatment with ammonium thiocynate formed 2-benzothiazolamines (II), which on reaction with hydrazine hydrate formed a hydrazino derivative (III). Compounds GG4 to GG8 were synthesized by reacting the hydrazine derivative with different acetophenones. All the synthesized compounds were identified by IR and 1H-NMR, and antimicrobial activity was performed on the synthesized compounds. Presence of NO2, Br, OCH3, and Cl groups to the substituted benzothiazole enhanced the antibacterial and antifungal activities.

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    G, A., G, K., R, K., A, S., & R, T. (2010). Synthesis, Characterization, and Biological Evaluation of certain 6-methyl-2(3H)-benzo-1, 3-thiazolyl-1'-ethylidene-2-(o, p- Substituted Acetophenones) Hydrazine Analogs. Journal of Young Pharmacists, 2(4), 394-398. https://doi.org/10.4103/0975-1483.71636

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    © 2010 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0