Safety and Effectiveness of Hydroxychloroquine in the Treatment of Type-2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Randomized Controlled Trials

    Published on:September 2022
    Journal of Young Pharmacists, 2022; 14(4):xx-xx
    Original Article | doi:

    Rahul Krishna Puvvada1, Pramod Adusumilli2, Raghava Kalyan Maddukuri2, Samaksha P B1, Manohar Gopal Annam3, Krishna Undela4,*

    1Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, INDIA.

    2Department of Pharmacy Practice, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur, Andhra Pradesh, INDIA.

    3Manager Pharmacovigilance, Advity Research Pvt Limited, Hyderabad, Telangana, INDIA.

    4Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research (NIPER) Guwahati, Assam, INDIA.


    Background: Type 2 diabetes is a metabolic disorder that requires continuous pharmacological treatment for its management. Due to the complexity of the treatment and increased risk of adverse reactions to the existing treatment, there is a need to demonstrate the safety and effectiveness of new medications. Therefore, this study was conducted to identify the safety and effectiveness of Hydroxychloroquine in people with type 2 diabetes. Methods: The Population, Intervention, Comparator, Outcome format was utilised to assess the inclusion criteria of randomized controlled trials. A total of five scientific databases were searched with the designed search terms. All the studies included were assessed for their risk of bias and a meta-analysis was performed by using RevMan. Results: A total of six randomized controlled trials were included in this systematic review. The majority of studies included hydroxychloroquine as an add on treatment for the existing treatment regimen. From the study results, it was found that hydroxychloroquine group effectively controlled blood glucose levels when compared with metformin or other treatment groups. Also, it was found that there was a significant reduction in the daily insulin requirement in the hydroxychloroquine treatment group. Despite the reduction in lipid profile in hydroxychloroquine group, there was no significant reduction in body weight observed between hydroxychloroquine and non-hydroxychloroquine groups. Lastly, hydroxychloroquine was well tolerated in people living with type 2 diabetes with less severe adverse effects. Conclusion: Overall, it was found that hydroxychloroquine significantly lowered the blood glucose levels when compared with people on other oral hypoglycaemic medications.

    Keywords: Hydroxychloroquine, Type 2 diabetes, Safety, Efficacy.