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A Study on Chemotherapy Induced Toxicities among Hospitalized Patients in Oncology Ward

1, 2★, 3★ Corresponding author

  1. 1Department of Oncology, Omega Speciality Hospitals, Hyderabad, Telangana, INDIA.
  2. 2Department of Pharmacy Practice, School of Pharmacy, Anurag University, Hyderabad, Telangana, INDIA.
  3. 3Department of Pharmacy Practice, Sultan-Ul-Uloom College of Pharmacy, Hyderabad, Telangana, INDIA.

CORRESPONDENCE

Divya Amaravadi

Department of Pharmacy Practice, School of Pharmacy, Anurag University, Hyderabad, Telangana, INDIA.

div4075@gmail.com

Received: 07-03-2025; Revised: 28-05-2025; Accepted: 18-07-2025.

Volume 17, Issue 3 · pp. 685-690 · 2025 · DOI: 10.5530/jyp.20250062

ABSTRACT

Background: Chemotherapy is an effective cancer treatment but chemotherapy-induced toxicity remains a major concern, as it can significantly affect patients' quality of life, lead to treatment intolerance and in some cases necessitate the discontinuation of therapy.Materials and Methods: A prospective observational study analysis of chemotherapy-induced toxicities conducted. Research done at Omega Cancer Specialty Hospital, Hyderabad for six-months duration in In-patient department of oncology ward. Study initiated after approval from Institutional ethics committee and obtaining the informed consent form patients. Above 16 years, both genders and patients with co-morbidities were included. Out-patients, cases below 16 years, pregnant women, nursing mothers and terminally ill patients excluded from study. SPSS version 24 implemented for statistical analysis. Confidence interval 95% and pvalue <0.05 considered significant. Associations between socio-demographic and clinical variables and chemotherapy-induced toxicities were evaluated using chi-square tests.Results: Out of 221 cases total of 349 chemotherapy-induced toxicities were documented. Majorly observed toxicities were leukopenia (31%), anemia (26%), and thrombocytopenia (24%). Females (67%) were more susceptible to toxicities than males (33%). Furthermore, patients aged (50-59) years were found to be at a higher risk of developing toxicity. Toxicity incidence was notably higher of 17% in patients undergoing dual therapy with (Paclitaxel and carboplatin) combination and during the second cycle of treatment.Conclusion: Chemotherapy-induced toxicities often lead to treatment delays, which can have detrimental consequences. Early identification can play a crucial role in clinical management, allowing for timely modifications in drug regimens to minimize toxicity and improve patient outcomes.

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    Ziauddin, M., Amaravadi, D., & Hussain, M. A. (2025). A Study on Chemotherapy Induced Toxicities among Hospitalized Patients in Oncology Ward. Journal of Young Pharmacists, 17(3), 685-690. https://doi.org/10.5530/jyp.20250062

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    © 2025 Author(s)

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