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Phenytoin Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: A Case Report

1, 1★, 1, 1, 1★ Corresponding author

  1. 1Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, SS Nagar, Mysuru, Karnataka, INDIA.

CORRESPONDENCE

Sujit Kumar Sah

Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, SS Nagar, Mysuru, Karnataka, INDIA.

sujitsah1913@gmail.com

Received: 06-01-2022; Revised: 24-02-2022; Accepted: 18-03-2022.

Volume 14, Issue 2 · pp. 253-255 · 2022 · DOI: 10.5530/jyp.2022.14.48

ABSTRACT

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an idiosyncratic and rare drug reaction that can be severe and life‑threatening if untreated. We present a 34 year old male patient, who developed DRESS syndrome after receiving phenytoin for 8 weeks and presented with rapidly progressive erythematous rash on trunk, face and upper extremities, fever and facial swelling. Abnormal laboratory findings, RegiSCAR score, and Naranjo’s probability scale revealed the association between phenytoin and DRESS syndrome. Phenytoin was withdrawn and adequately managed with systemic corticosteroids, antihistamine, and other symptomatic treatments. DRESS syndrome can be cured completely by early detection and removal of culprit drug along with other adequate symptomatic treatments.

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    Gosi, M., Sah, S. K., Merin, A., Dhurappanavar, S. N., & Kombettu, A. P. (2022). Phenytoin Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: A Case Report. Journal of Young Pharmacists, 14(2), 253-255. https://doi.org/10.5530/jyp.2022.14.48

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    © 2022 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0