Journal of Young Pharmacists logo
Submit
Journal of Young PharmacistsACADEMIC PUBLISHING
Article

Development and Validation of Microbiological Analytical Method for Determination of Potency of Voriconazole Tablets

1, 1★, 1, 1, 1, 1, 1, 1, 1, 2★ Corresponding author

  1. 1Department of Pharmaceutical Analysis, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, INDIA.
  2. 2Department of Biotechnology, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, INDIA.

CORRESPONDENCE

Sana Fathima

Department of Pharmaceutical Analysis, G. Pulla Reddy College of Pharmacy, Hyderabad, Telangana, INDIA.

fatimasana051@gmail.com

Received: 12-03-2020; Revised: 13-05-2020; Accepted: 02-07-2020.

Volume 12, Issue 2s · pp. s113-s116 · 2020 · DOI: 10.5530/jyp.2020.12s.58

ABSTRACT

A new microbiological method was developed for analysis of voriconazole tablets using Candida albicans as test microorganism. Various media, species and conditions were used to optimize the diffusion test. A prospective validation of the system showed adequate linearity (0.995), accuracy (RSD<2%) and consistency (mean recovery= 101.77%). High performance liquid chromatography was selected as a tool of comparison for evaluating voriconazole. Results of both the microbiological and HPLC methods have been compared with the student t-test and the voriconazole content determined by both methods has shown strong correlation. The developed microbiological analytical method provides true indication of biological activity and can be used in dosage forms for routine quality control analysis of voriconazole.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Sahitya, M., Fathima, S., Divya, A., Vaishali, K., NidhiSree, M., Reddy, C. S., Ramya, T. S., Rani, S., Padmavathi, Y., & Kiran, R. (2020). Development and Validation of Microbiological Analytical Method for Determination of Potency of Voriconazole Tablets. Journal of Young Pharmacists, 12(2s), s113-s116. https://doi.org/10.5530/jyp.2020.12s.58

    Copyright and licence

    © 2020 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0