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Clozapine Disrupts Endothelial Nitric Oxide Signaling and Antioxidant System for its Cardiovascular Complications

1, 1, 1, 1★★ Corresponding author

  1. 1Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, Kerala, INDIA.

CORRESPONDENCE

S K Kanthlal

Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus, Kochi, Kerala, INDIA.

skkanthlal@aims.amrita.edu

Received: 23-07-2018; Revised: 16-08-2018; Accepted: 13-10-2018.

Volume 11, Issue 1 · pp. 105-107 · 2019 · DOI: 10.5530/jyp.2019.11.22

ABSTRACT

Objective: Many drugs in current practice require additional safety labels in order to prevent potential risks to the major organ system. Psychotropic agent clozapine has been reported to produce myocarditis and other cardiac complications on repeated use. Our study aimed to establish the role of clozapine in vascular damage associated with nitric oxide metabolism.Method: Isolated aortic strips incubated with clozapine at different dose levels were estimated for nitrite release and antioxidant systems such as glutathione and catalase. Vascular integrity assessment was performed by recording the acetylcholine induced relaxation of phenyephrine precontracted aorta.Result: From our study, it was found that clozapine depilates the nitric oxide level in the endothelium and enhance the oxidative stress. The aorta fails to relax completely after adding acetylcholine indicates the deranged eNOS signaling in the endothelium.Conclusion: From the experimental findings, it was concluded that clozapine could depress the eNOS regulation and thereby perhaps initiates cardiovascular complications through subsequent vascular events.

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    Nair, G. M., Skaria, D. S., James, T., & Kanthlal, S. K. (2019). Clozapine Disrupts Endothelial Nitric Oxide Signaling and Antioxidant System for its Cardiovascular Complications. Journal of Young Pharmacists, 11(1), 105-107. https://doi.org/10.5530/jyp.2019.11.22

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    © 2019 Author(s)

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