Journal of Young Pharmacists logo
Submit
Journal of Young PharmacistsACADEMIC PUBLISHING
Article

Amelioration of 1, 2 Dimethylhydrazine Induced Tumor Promotion Response by Novel Benzimidazole Derivative Nanoparticle in Wistar Rats

1★, 2, 1, 1★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamil Nadu - 641 402, INDIA.
  2. 2Department of Pharmaceutical Chemistry, PPG College of Pharmacy, Saravanampatti, Coimbatore, Tamilnadu-641 035, INDIA.

CORRESPONDENCE

S.S. Rajendran

Department of Pharmaceutical Chemistry, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamil Nadu - 641 402, INDIA.

researchrajendran@gmail.com

Received: 05-03-2018; Revised: 09-04-2018; Accepted: 04-05-2018.

Volume 10, Issue 3 · pp. 292-298 · 2018 · DOI: 10.5530/jyp.2018.10.65

ABSTRACT

Background: Colon cancer is one of the most common malignancies in many regions of the world and is thought to arise from the accumulation of mutations in a single epithelial cell of the colon and rectum. The benzimidazole comprises a important pharmacophore and privileged structure in modern drug discovery. Various substituted benzimidazole derivatives have been found to possess potential anticancer properties.Objective: The study aimed to prove the anti-colon cancer activity of novel benzimidazole derivative 4-(1H-benzo[d]imidazol-2-yl)-6-phenylpyrimidin-2-amine loaded chitosan nanoparticle (BZI 3 nano) by an 1, 2 Dimethylhydrazine (DMH) Induced rat modelin-vivostudy and identify the targeting efficiency of BZI 3 nano to treat colorectal cancer.Method: The effect of novel benzimidazole derivative 4-(1H-benzo[d]imidazol-2-yl)-6-phenylpyrimidin-2-amine loaded chitosan nanoparticle (BZI 3 nano) on the formation of aberrant crypt foci (ACF), apoptosis, histopathology, body weight, organs weight and heamotological parameters were studied in 1,2-dimethylhydrazine (DMH)-induced colon cancer in rats.Results: BZI 3 nano (5 mg/kg, p.o) administration significantly reduced ACF number and increased the weight gain and apoptotic index compared to DMH treated group. The histological alterations induced by DMH were also significantly improved.Conclusion: In-vivo anticancer activities results revealed that the presence substituted benzimidazole derivative nanoparticle (BZI 3 nano) could have the anticancer potential of the scaffold and selective, good target for drug discovery, which can be regarded as promising anticancer potential.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Rajendran, S., Geetha, G., Venkatanarayanan, R., & Santhi, N. (2018). Amelioration of 1, 2 Dimethylhydrazine Induced Tumor Promotion Response by Novel Benzimidazole Derivative Nanoparticle in Wistar Rats. Journal of Young Pharmacists, 10(3), 292-298. https://doi.org/10.5530/jyp.2018.10.65

    Copyright and licence

    © 2018 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0