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Derivative Spectrophotometry Method for Simultaneous Estimation of Rupatadine and Montelukast in their Combined Dosage Form

1★, 2, 1, 1, 1★ Corresponding author

  1. 1Department of Pharmaceutical Chemistry, M.P. Patel College of Pharmacy, Jeevanshilp Campus, Kapadwanj, Dist-Kheda-387620, Gujarat, INDIA.
  2. 2Department of Pharmaceutical Chemistry, A.R. College of Pharmacy, Vallabh Vidyanagar, Gujarat, INDIA.

CORRESPONDENCE

Patel PG

Department of Pharmaceutical Chemistry, M.P. Patel College of Pharmacy, Jeevanshilp Campus, Kapadwanj, Dist-Kheda-387620, Gujarat, INDIA.

rajangnana76@yahoo.com

Volume 1, Issue 4 · pp. 354-358 · 2009 · DOI: 10.4103/0975-1483.59327

ABSTRACT

This study describes the development and validation for the simultaneous estimation of rupatadine and montelukast by the Þ rst-order derivative UV spectroscopy method. The quantiÞ cation was achieved by the Þ rstorder derivative spectroscopy method at 273.46 nm and 297.27 nm over the concentration range of 5-25 µg/ ml for estimation of rupatadine and montelukast in a combined tablet formulation. Procedure does not require prior separation of components from the sample. Rupatadine and montelukast were determined at 15 µg/ml with a mean recovery of 99.59 + 0.225 and 99.21 + 0.76, respectively. Calibration curves were linear with a correlation coefÞ cient of 0.9994 and 0.9992 for rupatadine and montelukast, respectively. The relative standard deviation was found to be <2.0%. The present result shows that the proposed method can be successfully used for simultaneous determination of the drug content in marketed formulations.

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    PG, P., VM, V., SG, R., NB, R., & VH, B. (2009). Derivative Spectrophotometry Method for Simultaneous Estimation of Rupatadine and Montelukast in their Combined Dosage Form. Journal of Young Pharmacists, 1(4), 354-358. https://doi.org/10.4103/0975-1483.59327

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    © 2009 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0