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Glucose-lowering, Hepatoprotective and Hypolipidemic Activities of Stem Bark of Ficus racemosa in Streptozotocin-Induced Diabetic Rats

1★, 1★ Corresponding author

  1. 1Department of Studies in Food Science and Nutrition, University of Mysore, Mysore-570006, INDIA.

CORRESPONDENCE

Ahmed F

Department of Studies in Food Science and Nutrition, University of Mysore, Mysore-570006, INDIA.

fayaz_ahmed09@yahoo.co.in

Volume 1, Issue 2 · pp. 160-164 · 2009 · DOI: 10.4103/0975-1483.55749

ABSTRACT

The present study evaluated the antihyperglycemic, hepatoprotective, and hypolipidemic effects of F. racemosa bark powder and aqueous extract in streptozotocin-induced diabetic rats. Streptozotocin-induced diabetic rats (n = 6) were treated with F. racemosa Linn (Moraceae) bark powder (FRP) and aqueous extract (FRAE) for six weeks. Blood glucose was determined every 15 days using a portable glucometer. At the end of the study period, the rats were sacriÞ ced and levels of serum glucose, protein, total cholesterol, triglycerides, AST, ALT, TBARS, and glutathione were determined as indicators of antihyperglycemic, hypolipidemic, and hepatoprotective activities, as well as of antioxidant potential. TBARS and glutathione levels were determined in the liver and the kidneys also. Both the bark powder and aqueous extract of F. racemosa bark caused a signiÞ cant reduction (P ≤ 0.05) in blood glucose (54 and 66% respectively). A signiÞ cant reduction (P ≤ 0.05) was also observed in serum cholesterol and triglyceride levels to the control levels. The aqueous extract was more effective and caused a signiÞ cant reduction (P ≤ 0.05) in TBARS, AST, ALT levels compared to untreated diabetic rats. However, it did not reach control levels. A signiÞ cant increase in glutathione concentrations over the control levels was also observed in rats treated with F. racemosa bark. It is concluded that F. racemosa bark has a signiÞ cant hypolipidemic and hepatoprotective effect besides being a potent antihyperglycemic agent.

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    F, A., & A, U. (2009). Glucose-lowering, Hepatoprotective and Hypolipidemic Activities of Stem Bark of Ficus racemosa in Streptozotocin-Induced Diabetic Rats. Journal of Young Pharmacists, 1(2), 160-164. https://doi.org/10.4103/0975-1483.55749

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    © 2009 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. CC BY-NC-SA 4.0