Antioxidant, Antinociceptive and Anti-inflammatory Activities of Ethanolic Extract of Leaves of Alocasia indica (Schott.)

    Published on:
    Journal of Young Pharmacists, 2010; 2(2):137-143
    Pharmacognosy | doi:10.4103/0975-1483.63152
    Authors:

    Mulla WA, Kuchekar SB1, Thorat VS, Chopade AR2, Kuchekar BS3

    Government College of Pharmacy, Vidyanagar, Karad 415 124,

    1Allana College of Pharmacy, Pune-411 001,

    2Rajarambapu College of Pharmacy, Kasegaon, Taluka, Walwa District, Sangli- 415 404, Maharashtra,

    3MAEER’s Maharashtra Institute of Pharmacy, Kothrud, Pune-411 038, India.

    Abstract:

    Extracts obtained from the leaves of various Alocasia species have been used in India as folk remedy for the treatment of various inflammatory ailments including rheumatism and bruise. The ethanolic extract of leaves of Alocasia indica Schott. was evaluated by using different in vitro antioxidant models of screening like scavenging of 1, 1-diphenyl-2-picryl hydrazyl (DPPH) radical, nitric oxide radical, superoxide anion radical, and hydroxyl radical. The antinociceptive activity was tested by acetic acid-induced writhing response, hot plate method, and tail flick method in albino rats. The anti-inflammatory potential of gels of ethanolic extract has been determined by using carrageenan-induced paw edema assay, formalin-induced paw edema assay, arachidonic acid-induced ear edema assay, and xylene-induced ear edema assay. The extract showed remarkable antioxidant activity in all models, comparable to the standard reference drug ascorbic acid. The ethanolic extract of Alocasia indica and its gels produced dose-dependent antinociceptive and anti-inflammatory activity, respectively. This finding suggests that ethanolic extract of A. indica possess potent antinociceptive and anti-inflammatory activity possibly due to its free radical scavenging properties.

    Key words: Alocasia indica Schott, antioxidant, antinociceptive, anti-inflammatory, ascorbic acid, diclofenac.

     

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