Ivabradine: Novel If Channel Inhibitor

    Published on:
    Journal of Young Pharmacists, 2009; 1(3):284-284
    Letter to Editor | doi:10.4103/0975-1483.57073

    Ameya H, Kumar A1

    Faculty of Medicine, AIMST University;

    1Unit of Pharmacology, Faculty of Medicine, Malaysia.


    Pacemaker activity of the heart involves interplay between several ionic currents that inß uence spontaneous diastolic depolarization of the sinoatrial node, including If current. The search for pure heart rate-lowering agents to prevent angina without over all adverse effects of β-blockers[1] began more than three decades ago. The discovery of If current and If channels offered a possible approach to the developing pure heart rate-lowering agents.[1]