Ivabradine: Novel If Channel Inhibitor

    Published on:
    Journal of Young Pharmacists, 2009; 1(3):284-284
    Letter to Editor | doi:10.4103/0975-1483.57073
    Authors:

    Ameya H, Kumar A1

    Faculty of Medicine, AIMST University;

    1Unit of Pharmacology, Faculty of Medicine, Malaysia.

    Abstract:

    Pacemaker activity of the heart involves interplay between several ionic currents that inß uence spontaneous diastolic depolarization of the sinoatrial node, including If current. The search for pure heart rate-lowering agents to prevent angina without over all adverse effects of β-blockers[1] began more than three decades ago. The discovery of If current and If channels offered a possible approach to the developing pure heart rate-lowering agents.[1]

     

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