Supplementation of Carica papaya Leaves (Carica papaya L.) in Nori preparation Reduced Blood Pressure and Arterial Stiffness on Hypertensive Animal Model

    Published on:March 2020
    Journal of Young Pharmacists, 2020; 12(1):xx-xx
    Original Article | doi:10.5530/jyp.2020.12.x

    Patonah Hasimun*, Agus Sulaeman, Intan Dwi Puspita Maharani

    Faculty of Pharmacy, Bhakti Kencana University, Bandung, West Java, INDONESIA.


    Objectives: Hypertension is defined as an increase in systolic and/or diastolic blood pressure of more than 140/90 mmHg. Epidemiological studies showed that there is a relationship between hypertension and the incidence of arterial stiffness, especially in the elderly. Blood pressure management aims to prevent damage to various target organs such as the heart, brain, kidneys, eyes and peripheral arteries. Papaya leaves (Carica papaya L.) have been known empirically to treat hypertension. This study aimed to determine the effect of papaya leaves processed into Nori preparation on blood pressure and arterial stiffness. Methods: This study was carried out on animal models of male Wistar rats induced hypertension. A total of 30 male-Wistar rats were randomly divided into 6 groups consisting of control negative group and control positive group (received drug carriers), the group received captopril 2.5 mg/kg and groups received Nori of papaya leaves 5, 10 and 20% in their diet. All groups except the control negative group received 66% fructose in their food for 21 days. Parameters measured were systolic and diastolic blood pressure, pulse wave velocity (PWV) on days 0, 7, 14 and 21 after treatment. Results: The group received Nori 10% showed normalize both systolic and diastolic blood pressure and a decreased in arterial stiffness compared to the group received captopril (p>0.05). Conclusion: It can be concluded that papaya leaves in Nori preparation is effective as an antihypertensive and reduced arterial stiffness.

    Key words: Arterial stiffness, Blood pressure, Carica papaya L., Hypertension, Pulse wave velocity.