The Evaluation of Serum Levels of Erythrocyte Sedimentation Rate and C-reactive Protein with CA125 as Probable Predictive Factors of Malignancy in Adnexal Masses

    Published on:July 2019
    Journal of Young Pharmacists, 2019; 11(3):304-308
    Original Article | doi:10.5530/jyp.2019.11.61

    Zeinab Nazari1, Afsane Rastegar1,*, Mehdi Nasouhi2, Elham Bani Mostafavi3, Fatemeh Montazer4

    1Department of Medical Science, Mazandaran University of Medical Science, Mazandaran, IRAN.

    2Department of Medical Science, Babol University of Medical Science, Babol, IRAN.

    3Department of Medical Science, Mazandaran University of Medical Science, Mazandaran, IRAN.

    4Department of pathology, Gastrointestinal Cancer Research Center, Imam Hospital, Mazandaran university of Medical Sciences, Sari, IRAN.


    Background: Adnexa masses include ovarian masses, fallopian tubes and surrounding connective tissues and are among the most important and common disorders of women’s science. The aim of this study was to investigate the levels of serum ESR and CRP changes along with CA- 125 in patients with adnexal tumors. Methods: This research was a crosssectional study. The statistical population consisted of all patients who referred to Imam Khomeini Hospital of Mazandaran University of Medical Sciences during 12 months from September 2016 to September 2017 with diagnosis of adnexal mass and undergoing surgery. The sample size was 100 people who were selected through convenience sampling method. The method of data collection was such that a blood sample was taken from all patients who were candidates for adnexa masses surgery and kept at room temperature for 30 min and then centrifuged for 10 min at 4000 rpm. Data were analyzed using Mann-Whitney U test, correlation coefficient and logistic regression analysis. Results: The findings showed that elevated levels of CA125, ESR and CRP were not significantly correlated with tumor type and could not be used for screening alone. However, in cases of malignant tumors, its increased levels may indicate a higher staging of the tumor. Conclusion: According to the results, evaluation of the level of tumor marker CA125 and inflammatory markers of ESR and CRP in malignant tumor can be used to determine appropriate diagnostic therapeutic measures.

    Key words: Adnexal masses, CA125, C-reactive protein, Erythrocyte sedimentation rate.

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