Objective: To generate a hydrogel to increase the retention time of a drug in an ophthalmic drug delivery system. Methods: Research was conducted on the formulation and evaluation of a safe-to-use chloramphenicol ophthalmic hydrogel with various concentrations of hydroxypropyl methylcellulose (HPMC), F1 (0.2 % HPMC), F2 (0.3 % HPMC), F3 (0.4 % HPMC) and F4 (0.5 % HPMC). The organoleptic safety, pH, viscosity, sterility, potency, and in vitro drug release were evaluated. Results: The drug concentration had dissimilar effects on viscosity and release rate. F4 (0.5 % HPMC) had the least chloramphenicol diffused at 5 min (11.01 %) and after 8 h (71.13 %). The in vitro drug release from the hydrogel was significantly influenced by the HPMC concentration, which enhanced the bioavailability through longer pre-corneal residence time and the ability to sustain the release of the drug. Conclusion: The chloramphenicol hydrogel ophthalmic preparations formulated with HPMC have shown a good characteristic, and acceptable sustained released profile that may extend absorption of the drug for ensuring an optimum bioavailability at the site of action. The finding of this study indicated that chloramphenicol hydrogel ophthalmic preparations for the ophthalmic treatment was good is effective and safe.
Key words: Chloramphenicol, Hydrogel, Hydroxypropyl methylcellulose, Ophthalmic.