Nebivolol: An Appealing, Awaited and Nitric Oxide Potentiator Drug for the Treatment of Heart Failure

    Published on:April 2018
    Journal of Young Pharmacists, 2018; 10(2):149-154
    Original Article | doi:10.5530/jyp.2018.10.34

    Aryendu Kumar Saini1*, Pranay Wal1, Manisha Verma2, Suresh Chandra1, Anurag Singh1, Sanjeev Yadav1, Himanshu Bansode1, Kumar Nischaya1, Nikita Saraswat1

    1Pharmacy Department, Pranveer Singh Institute of Technology, Kanpur, Uttar Pradesh, INDIA.

    2Department of Clinical Research, National Institute of Pharmaceutical Education and Research, Mohali, Punjab, INDIA.


    Nebivolol is a third generation beta-blocker that possesses the highest selectivity for beta-1 receptors than beta-2 receptors than any other beta blocker in its class. Long-term therapy of nebivolol, in clinical trials, has been found to be very effective in increasing the left ventricular ejection fraction, reducing all-cause mortality, and reducing the New York Heart Association (NYHA) class of heart failure. The novelty of nebivolol exists in its unique nitric oxide potentiating effects in the myocardial and endothelial cells by the activation of beta-3 adrenergic receptors by which it produces most of its actions. It produces many useful effects and helps to abate the disease progression and prolongs the survival. In many clinical studies, it has been found to be safe and well tolerated. A literature search was made on PubMed database with the keywords: “Heart failure”, “Nebivolol”, and “beta- blocker”. A total of 176 articles were found and were the combination of review articles and research articles. A further selection of articles was made by the exclusion of non-relevant articles to achieve the objective of this review. It is approved for the treatment of hypertension in the United States and is under review by the federal agency, United States Food and Drugs Administration for the treatment of heart failure. This article sole intention is to review all the clinically important aspects of nebivolol on the basis of which nebivolol can be definitely considered for its inclusion in the drug therapy list for heart failure which will ease the individualization of drug therapy.

    Key words: Cardiac remodeling, Heart failure, Hypertrophy, Nebivolol, Nitric oxide, Systolic dysfunction.

    Article Download