Objective: The goal of the study was to formulate and characterized the pH stimuli sensitive based hydrogels for the effective treatment of infected eye. Method: Simple method of preparation was adapted. Result: The optimized formulations was undergone the characterization studies such as XRD spectrum analysis, FTIR analysis, Gelling capacity, Drug content, Determination of viscosity, surface tension of the optimized formulations, DSC analysis, in-vitro release study of the optimized formulations, Ex-vivo release studies of best formulation and stability studies. The pre-formulation studies confirm the drug and polymer are compatible with each other. The F5 formulation showed the maximum percentage of drug release around 97.08% in drug release study. The ex-vivo study showed 95.57% of drug release for the period of 7 h. Further, the optimized formulations were most stable in room temperature when compared to higher temperature. Conclusion: The prepared formulations of pH based hydrogels were optimized; developed formulations are used as treatment for ocular drug delivery system with increase in precorneal time, reduced frequency of the dosage and to achieve the patient compliance.
Key words: Hydrogels, Viscosity, Ex-vivo study, Stimuli, Sensitive, Gelling Capacity.