Development and Evaluation of Mouth Dissolving Tablets using Natural Super Disintegrants

    Published on:July 2017
    Journal of Young Pharmacists, 2017; 9(3):332-335
    Original Article | doi:10.5530/jyp.2017.9.66

    Venkatalakshmi Ranganathan*1, Jason Yoong2

    1School of Pharmacy, MAHSA University, Jalan SP 2/7, Bandar Saujana Putra, Jenjarom, Selangor, MALAYSIA.

    2School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, MALAYSIA.


    Objective: To formulate a mouth dissolving tablets of dexamethasone for the use of paediatrics, geriatric patients and also dysphagic patients. Methodology: Tablets were formulated by using different types of natural Super disintegrants in different concentration such as Guar gum and Xanthan gum. A manual 7 mm single punch tablet compression machine was used to compress the tablet. Powder mixture of 150mg was weighed accurately and added into the die cavity. The prepared dexamethasone MDT tablets were evaluated for its physico-chemical parameters such as thickness, hardness, weight variation, friability, disintegration time, wetting time, in-vitro dispersion time, water absorption ratio and also in-vitro drug release. Results: The FTIR and DSC studies conferred that there is no interaction between dexamethasone and Super disintegrants. The dissolution profile of dexamethasone MDT compared with conventional dexamethasone tablet shows improved in % drug release and faster % drug release. An increase in the concentration of Super disintegrants showed faster % of drug release and similar % of cumulative drug release. Conclusion: Dexamethasone MDT using Guar Gum and Xanthan Gum could be considered as good formulation and delivery system to increase the patient’s compliance as the % drug release and disintegration time are much better than conventional Dexamethasone tablet.

    Key words: Mouth Dissolving Tablets, dexamethasone, Super disintegrants, Rapid disintegration, Dysphagia.

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